Machine guns dikategorikan sebagai senjata utama weapon.Machine sepenuhnya otomatis dan merupakan jenis dipasang atau portabel senjata api, biasanya dirancang untuk api putaran berturut-turut dari amunisi belt atau berkapasitas besar magazine, biasanya pada tingkat beberapa ratus putaran per menit. Banyak digunakan dalam Zombie Mods, Zombie Skenario, Deathmatch dan Team Deathmatch.
QBB-95 is a Chinese light machine gun that fires 75 rounds of 5.8×42mm ammunition. It is accurate in long range if fired in burst and has good rate of fire. However, it is not suitable for continuous fire due to its high recoil and spread. QBB-95 is usually used in Deathmatch and Team Deathmatch modes.
QBB-95 Extra Magazine is a modified version of the QBB-95. It shares the same performance except it can load 5 more rounds in its magazine and has 400 rounds as reserved, making it useful in Zombie Mods.
FN Minimi or M249 for American version, is a light machine gun that fires 100 rounds of 5.56×45mm NATO ammunition. It has greater recoil and bullet spread, making it ineffective in long range. It is usually used by the player in Zombie Scenario Mode.
Veteran version for M249. Fix almost all the performance (damage, accuracy, recoil, rate of fire and weight) and added a new function: [Buttstock Knock].
HK23E is a light machine gun that is fed with 100 rounds of 5.56 NATO ammunition. It is lighter than M249 by 3% but it has lower firepower by 1%. Plus, it is cheaper than M249 and has shorter reload time.
M60E4 is a general purpose machine gun that fires 100 rounds of 7.62 NATO ammunition. It shares most of the M249 properties except it does greater damage, cheaper and shorter reload time.
MG36 is a light machine gun fed with 100 rounds of 5.56 NATO rifle cartridge in a C-MAG drum magazine. When compared to M249, it is a lot cheaper, does higher damage, has lower recoil higher rate of fire, lighter, has the ability to zoom and shorter reload time but it has lower accuracy.
MK48 is a 7.62mm light machine gun designed for US Special forces. It is fed with 120 rounds in an ammo box and comes with a usable scope. This weapon is as light as the HK23 and MG36 and much more powerful than the SKULL-7. However, it has very low rate of fire.
Izmash PKM is a moderate machine gun that is fed with 150 rounds of 7.62 NATO ammunition. It does moderate damage and can be fired in 3-round burst. However, it is expensive, has low fusillade, expensive ammo cost and takes a long time to reload.
MG3 is a general purpose machine gun that is fed with 200 rounds of 7.62×51mm NATO ammunition. It has high magazine capacity and rate of fire. It was released same along with Zombie Scenario and widely used in Zombie Mods.
M134 Minigun is a Zombie Mods-exclusive machine gun which fires 200 rounds of 7.62 NATO. It is designed exclusive for zombie battles and less effective in Original, Deathmatch and Team Deathmatch modes.
Avalanche is a science fiction machine gun which is fed with 200 rounds of 7.62 NATO bullets in a box magazine. This gun can be freely switched to A mode (High damage, low fire rate) or B mode (Low damage, high fire rate).
Daewoo Precision Industries K3 is a light machine gun resembling the FN Minimi and uses a standard 5.56 NATO cartridge. This gun replaced the MP5 as spawn primary weapon in Zombie Scenario.
M2 Browning is an American heavy machine gun fed with 250 rounds of .50 BMG used during World War II. It is deployable and can do massive damage due to its high caliber rounds.
The Browning M2HB is a mounted heavy machine gun which is usable in Decoy, Angra Nest, Threat, Urban Assault and City of Damned. This machine gun is fed with 250 rounds of .50 BMG cartridges in an ammo box. The player can use it by walking to the machine gun and press the USE button (Default: E).
SKULL-7 or M249EX is an anti-zombie version of the M249. It holds 120 rounds of 5.56mm Anti-zombie and 240 rounds as reserve. It deals large amount of damage per bullet to zombies, penetrate the zombie's Kevlar and has the function to zoom. Skull-7 is released alongside with map Chaos and sold for limited time only.
SKULL-8 is an anti-zombie machine gun fed with 120 rounds of 5.56mm Anti-zombie ammunition. It is attached with a light weight axe bayonet under its barrel for emergency melee combat. Its primary fire has superior penetration towards zombie's armor.
SKULL-6 is an anti-zombie machine gun fed with 100 rounds of 5.56mm Anti-zombie and equipped with a sniper scope for long range engagement. Its bullets develops superior penetration and do deadly damage to zombies. When using the scope, it is more accurate but the rate of fire is decreased.
JANUS-7 is the modified version of Rheinmetall MG3 by Aegis Laboratory. It is fed with 200 rounds of 7.62mm and equipped with Janus Transformation System that can do tremendous damage after continuous fire.
This is the modified version of M60E4 that holds 200 rounds of 7.62 mm. It is modified by a terrorist cell and can only be obtained from Craft. This version also has a usable scope attached.
This is the modified version of M134 Minigun that holds 200 rounds of 7.62 mm. When equipped with other Journey to the West weapons, its weight will be reduced, allowing the user to move faster.
This is a steam-operated machine gun fed with 150 rounds of 5.56 mm. Firing this weapon will accumulate steam for secondary fire, which functions as flamethrower. Aeolis can only be obtained from Coded Box.
This is a general purpose machine gun originated from Nazi Germany to hold 95 rounds of 7.62 NATO. It was firstly invented in 1942 and later involved during the World War II and Portuguese Colonial War. The usage of drum magazine makes this machine gun has high mobility, resulting it as a dominating weapon in World War II and even nicknamed as "Hitler's buzzsaw" or more coarsely, "Hitler's zipper".
This is a machine gun fed with 100 rounds of 5.56 NATO allocated in 5 different chambers, resulting in 20 rounds per chamber. When reloading, it is reloaded per chamber and takes 5 minutes to do a full reload. However, the reload can be cancelled, like a regular shotgun, to be fired while reloading.
This is an anti-zombie machine gun fed with 120 rounds of 7.62 NATO. It is developed by the Aegis Institute and based on the Belgian MK48. It is equipped with the Thanatos Blade System which can deal continuously high damage to multiple targets inside the blades' radius.